A Safair Boeing 737-800, registration ZS-FGE performing flight FA-212 from Johannesburg to Cape Town (South Africa), was departing from Johannesburg’s runway 21R when the outboard left main wheel separated from the airframe. The crew stopped the climb at about FL220, descended to FL150 and entered holds to burn off fuel. The aircraft performed a low approach to runway 21R about 90 minutes after departure, entered another hold and landed safely on runway 21R about 40 minutes after the low approach and about 2:15 hours after departure.
The lost wheel was recovered within the airport perimeter.
Source – Aviation Herold